At about 3.30am on 18 July, police officers on patrol witnessed a vehicle collide with the Blackfriars Pub on Blackfriars Road, Salford, and subsequently catch fire.
The front door of the historic building which was due to reopen this month was left damaged.
Two male casualties were rescued from the vehicle by police officers, who then tried to put out the fire.
NWAS and GMFRS also attended and the two men were taken to hospital where one of the men, the passenger aged 23, has sadly died despite the best efforts of the emergency services.
The driver, also 23, remains in a serious but stable condition in hospital.
There is a scene in place and an investigation by GMP's Serious Collision Investigation Unit is under way.
PC Andrew Nicholson said:
"This is a tragic incident in which a man has sadly lost his life. Our thoughts remain with his loved ones at this incredibly difficult time.
"I would also like to praise the bravery of the officers who rescued the men from vehicle and the work of the emergency services at the scene.
"An investigation is under way into the circumstances leading up to the crash - anybody with information or dashcam footage of this collision is asked to call police on 0161 856 4741 quoting log 594 of 18/07/21."
Information can also be reported online or by using the Live Chat function at www.gmp.police.uk.
If you can't report online, call 101 or Crimestoppers anonymously on 0800 555 111.