Emergency services were called to Great Clowes Street in the early hours of this morning after a collision between a pedestrian and a car.
A male in his 20's suffered injuries to his legs and wrists and was taken by ambulance to Manchester Royal Infirmary for treatment.
Additionally a young female passenger within the car also required treatment and was taken to Salford Royal.
Commuters were faced with the road being closed as they headed out to work but it was not long before it was reopened again.
A NWAS spokewoman said:
"We were called at around 2:59am to a road traffic collision involving a car and a pedestrian.
"Two vehicles were sent.
"A teenage female was outside of the car by the time we arrived on the scene.
"She did not have serious injuries, she was conscious and breathing. She was taken to Salford Royal Hospital.
"We have also got a male in his 20s. He suffered leg and wrist injuries. He was taken to the MRI."