Police were called to an incident in Irlam at around 3pm on Friday, upon arrival at the scene on Silverdale Avenue they discovered a 50-year-old man with injuries consistent with having been stabbed.
He was taken to hospital but sadly died due to his injuries on Saturday evening.
A 17-year-old boy was arrested and charged with the mans murder, a 48-year-old woman named by police as Nancy Smith (14/6/71) of Manchester Road East, has also been charged with assisting an offender.
The 17-year-old can not be named for legal reasons.
Both have been remanded into custody and are set to appear at Manchester City Magistrates Court on Monday 2 September 2019.